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Help prevent bone problems in breast cancer patients with bone metastases
Help prevent bone problems in solid tumor patients with bone metastases
Help prevent bone problems in prostate cancer patients with bone metastases

Help protect your bones when cancer spreads

Learn about the importance of preventing bone problems with XGEVA® in patients with bone metastases from solid tumors

About XGEVA®

  • XGEVA® (denosumab) is a prescription medicine used in patients with bone metastases from solid tumors to prevent bone problems that are broken bones (fractures), surgery to prevent or repair broken bones, radiation treatments to bone, and pressure on the spinal cord (spinal cord compression)
  • XGEVA® (denosumab) is given as a single shot under the skin (subcutaneous), once every 4 weeks
  • XGEVA® (denosumab) does not involve the use of an infusion through a vein

Indication

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with bone metastases from solid tumors.
XGEVA® is not used to prevent these bone problems in patients with multiple myeloma.

Important Safety Information

Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®.
XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

XGEVA® contains the same medicine as Prolia® (denosumab). If you are taking XGEVA® do not take Prolia®.

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.


Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.


Please see Full Prescribing Information.